APPLICATION OF RED DRAGON FRUIT ON HEALING MUCOSAL WOUNDS OF WISTAR RAT

Sari  Kusumadewi; Komang  Dina Sintya Dewi; IGAA  Anggita Dewi Hartayani; Viata  Da Silva Pinto

Authors

Sari Kusumadewi Department of Dentistry, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
Komang Dina Sintya Dewi Student of Dentistry, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
IGAA Anggita Dewi Hartayani Student of Dentistry, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
Viata Da Silva Pinto Student of Dentistry, Faculty of Medicine, Universitas Udayana, Bali, Indonesia

Keywords:

angiogenesis, red dragon fruit, wound healing

Abstract

Red dragon fruit contains flavonoids that play role in wound healing. The purpose of this study was to determine the effect of red dragon fruit on the healing of oral mucosal wounds of Wistar rats. The research method used post test only control group design by making 3 groups: treatment, positive and negative control. Each group was further divided into 3 small groups based on time: 3, 5 and 7 days, so there were total of 9 small groups with 4 rats each. The research data were analyzed for normality test with Saphiro-Wilk, homogeneity with Levene's test, followed by two-way ANOVA test and LSD Post Hoc. The results were divided into 3 observation groups. Group-1 Epithelial cell thickness: The highest mean value of epithelial cell thickness was in the treatment group on days 3 and 5. Group-2 Number of fibroblast cells: The highest mean value of fibroblast cell: treatment group (63.22) > control group (56.22) > negative group (47.44). Group-3 Angiogenesis: The highest mean angiogenesis value was in the treatment group on days 3 and 5. It was concluded that the application of red dragon fruit (Hylocereus polyrhizus) affected the healing of wistar rats (Rattus norvegicus) buccal mucosal wounds.

DOI : 10.54052/jhds.v2n3.p375-386